Formulation and Evaluation of Divalproex Sodium Enteric Coated Tablets
نویسندگان
چکیده
Divalproex sodium Chemically it is designated as sodium hydrogen bis(2-propylpentanoate) is a stable co-ordination compound comprised of sodium valproate and valproic acid in a 1:1 molar relationship and formed during the partial neutralization of valproic acid with 0.5 equivalent of sodium hydroxide. Divalproex sodium is an anticonvulsant drug. Increase level of gama-amino butyric acid in brain & reducing the suizure action. Immediete release tablet of divalproex sodium, Before enteric coating is formulated by optimization of two binding agent (PVP K30 and PVP K90) The Enteric coating were optimized by using two different enteric coating polymer(HPMCP 50 and Eudragit L100). The results of the in vitro release studies showed that the optimized formulation (F11) delayed the release of drug for 1 h in acidic medium. The prepared tablets were evaluated in terms of their precompression parameters, physical characteristics.
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